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Research Use Only
M30 Apoptosense® ELISA is a unique tool for reliable and reproducible quantitative detection of apoptosis of keratin 18 (K18) (cytokeratin 18 [CK18]) positive cells. The assay is intended for subject sera. Another useful application is the detection of tumor apoptosis in mouse xenograft models using plasma samples.
M30 Apoptosense® is an ELISA assay based on the M30 monoclonal antibody (Leers et al., 1999). This antibody specifically binds caspase-cleaved keratin 18 (ccK18, caspase-celaved cytokeratin 18, ccCK18 or K18-Asp396) but does not bind native, uncleaved, K18. The M30 Apoptosense® assay therefore represents a specific quantitative test for apoptosis in epithelial cells (Hägg et al. 2002).
All reagents are provided in a convenient ready-for-use format. The separable strips provide the flexibility for your experimental design.