DISCONTINUED

Intended Use

Protein C Normal Control Plasma is used for day-to-day control of Protein C assays.

Principle

Protein C is a Vitamin K-dependent anticoagulant protein that normally circulates in plasma as the inactive zymogen. After activation, Protein C proteolytically degrades factors V and VIII, thus prolonging the clotting time.

Protein C Normal Control Plasma is a freeze-dried preparation of normal human plasma for which the Protein C activity has been determined. The antigen level is assayed by ELISA. The Protein C activity is assayed using both a clottable assay and a chromogenic assay. Both the clotting and chromogenic assay systems employ a Protein C-specific snake venom fraction to activate Protein C.

Reagent -- Composition, Packaging, Storage and Stability

Protein C Normal Control Plasma: 10 vials of 0.5ml, freeze-dried. Each vial contains normal human plasma prepared from a pool of normal donor plasmas that were anticoagulated with sodium citrate, buffered, and rapidly processed to preserve the plasma Protein C.

All unreconstituted reagents are stable until the expiration date stated on the box and vial labels when stored at 2-8°C.