The Biopool Ristocetin Cofactor Assay is 510k-cleared kit for the quantitative determination of Factor VIII Ristocetin Cofactor activity in plasma.

Principle

Following reconstitution, the lyophilized platelets are treated with Ristocetin in the presence of dilutions of a normal standardized human plasma with known amounts of Ristocetin Cofactor activity. A standard curve is prepared. A patient plasma is then used as a source of Ristocetin Cofactor activity in the presence of Ristocetin and reconstituted platelets from which an aggregation pattern (slope) is determined. The Ristocetin Cofactor activity is interpolated from the standard curve.