DISCONTINUED

High Molecular Weight Kininogen (HK) is a nonenzymatic cofactor of the contact activation system. HK is thought to have two functions in the contact activation system. First, HK links prekallikrein to a negatively charged surface thereby allowing activation to kallikrein by surface bound Factor a-Xlla. HK also forms a complex with Factor XI and accelerates its activation to XIa by a-Xlla. Also HK serves as a source of Bradykinin, a potent Vasoactive peptide important in Hypotension studies. ERL offers single chain HK (>95% single chain) with a specific clotting activity of approximately 14 u/mg.

Buffer composition = 4 mM Sodium Acetate-HCl/0.15 M NaCl/pH 5.3
*Extinction Coefficient (1%) = 7.01
Molecular Weight = 120,000 daltons