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Activated Protein C (APC)

Can I freeze the reagents in the Coatest APC resistance kits to prolong their stability?: The APTT reagent cannot be frozen. The other reagents can, but should be rapidly thawed at 3...
Can I use Coatest APC Resistance V without the predilution with FV deficient plasma? Isn’t this just like using the APC R kit?: No. There is more APC in the APC V kit than in the classic kit. This makes the APC ratios tw...
Describe the interaction between Protein S and APC.: Only the free, native form of PS binds to APC and functions as a cofactor. PS has the highes...
Describe the protein C pathway and APC resistance. What is the relative risk of venous thrombosis for those who are APC resistant?: Protein C is a vitamin-K-dependent glycoprotein and plasma proenzyme of a serine protease th...
Explain the types of protein C deficiency, and the clinical manifestations.: Hereditary protein C deficiency is inherited as an autosomal dominant trait. Heterozygotes f...
How do factor V and VIII levels affect the Coatest APC Resistance tests?: A study by Colucci et al. (Thromb. Haemost. 1994, 72:987 - 988) using the classical APTT met...
What effect does variation of plasma levels of protein C have on the APC ratio?: Variations in plasma levels of protein C have no influence on the APC ratio since a standard...
What is the normal baseline range for the APTT reaction? What types of conditions might cause a patient to give abnormal aPT time, and what can be done about it?: The normal range is approximately 25-40 seconds, although it will vary slightly depending on...
Which assay should I run – Coatest APC Resistance or Coatest APC Resistance V?: During the last years recent publication have been showing that the APC Resistance phenotype...