Antithrombin (AT)
Chromogenix Coamatic Antithrombin
Chromogenic / IVD
Catalog #: K821991 (821991)
A chromogenic kit for in vitro diagnostic determination of antithrombin activity in human plasma. The use of factor Xa in preference to thrombin eliminates interference from heparin cofactor II and thrombin inhibitors.
The FXa-based assay has been shown to discriminate better between AT-deficient and non-AT-deficient individuals than a thrombin-based assay [Demers et al 1993]. It also gives accurate results in patients who are receiving heparin therapy [Bohner et al 1994].
Simple, accurate and convenient. All methods are based on FXa inhibition. Allows accurate determination of antithrombin in patients receiving heparin therapy. Superior reagent stability. Validated and documented protocols for a wide range of instruments. Suitable for both large and small laboratories.
Features of Coamatic Antithrombin:
- Use of FXa instead of thrombin eliminates interference from heparin cofactor II anddirect thrombin inhibitors
- Highly sensitive FXa chromogenic substrate and superior reagent stability
- High accuracy and precision - CV values less than 5%
- Applications available for a wide range of automated coagulation analyzers, including the BCS
- Accurate determinations in patients receiving heparin therapy
- Suitable for both large and small laboratories
Antithrombin Pathway
Measurement principle
|
AT + Heparin |
----------------------> |
[AT · Heparin] |
|
[AT · Heparin] + FXa (excess) |
----------------------> |
[AT · Heparin·FXa] + FXa (residual) |
|
S-2765 |
----------------------> |
Peptide + pNA |
AT = Antithrombin
Reagents and Stability when opened
|
Substrate S-2765 |
1 vial |
6 months |
2-8°C |
|
Buffer with Heparin |
1 vial |
3 months |
2-8°C |
|
FXa |
1 vial |
3 months |
2-8°C |
Number of determinations: 50 (test tube), 200 (microplate), up to 130 (automated)
Downloads
| Name | Type | Size |
|---|---|---|
| Chromogenix Coamatic / Coatest Thrombophilia Flyer | application/pdf | 536.13 kB |
| Coamatic Antithrombin Brochure | application/pdf | 265.61 kB |
| Coamatic Antithrombin Flyer | application/pdf | 395.69 kB |
| Coamatic Antithrombin Monograph | application/pdf | 179.53 kB |
| Coamatic Antithrombin MSDS | application/pdf | 84.75 kB |
| Coamatic Antithrombin Package Insert | application/pdf | 91.56 kB |
Downloads (Historical Files)
| Name | Type | Size |
|---|---|---|
| Coamatic Antithrombin 1995 (old) | application/pdf | 2.80 MB |
| Coamatic Clinical Products Flyer - Antithrombin and Protein C | application/pdf | 5.23 MB |