APC Resistance (APCR)
Chromogenix Coatest APC Resistance
Clotting / IVD
Catalog #: K822643 (822643)
For in vitro diagnostic use
An APTT-based assay for the detection of the APC resistance phenotype, i.e. the poor anticoagulant response to activated protein C (APC). The test result (APC ratio) gives an estimation of the anticoagulant function in vivo and provides information on the thrombotic risk associated with inherited and acquired APC resistance. Detects the APC resistance phenotype regardless of its cause. Detects both inherited and acquired APC resistance.
Measurement principle (Coatest APC Resistance)
Plasma is incubated with the APTT reagent for a standard period of time. Coagulation is initiated by the addition of CaCl2 in the absence and presence of APC and the time for clot formation is recorded.
Reagents and Stability when opened
|
Reagent |
Units APC V |
Units APC VS |
Units APC |
Expiration |
Temperature |
|
V-DEF Plasma |
4 × 4 mL |
2 × 4 mL |
n/a |
8 hours |
15-25°C |
|
24 hours |
2-8°C |
||||
|
3 months |
-20°C |
||||
|
CaCl2 |
1 × 8 mL |
2 × 2 mL |
2 × 2 mL |
1 week |
15-25°C |
|
1 month |
2-8°C |
||||
|
APTT Reagent |
1 × 16 mL |
2 × 4 mL |
2 × 4 mL |
1 week |
15-25°C |
|
1 month |
2-8°C |
||||
|
APC/CaCl2 |
4 × 2 mL |
2 × 2 mL |
2 × 2 mL |
8 hours |
15-25°C |
|
5 days |
2-8°C |
||||
|
3 months |
-20°C |
||||
|
Control level 1 |
1 × 1 mL |
1 × 1 mL |
n/a |
6 hours |
15-25°C |
|
3 months |
-20°C |
||||
|
Control level 2 |
1 × 1 mL |
1 × 1 mL |
n/a |
6 hours |
15-25°C |
|
3 months |
-20°C |
||||
Downloads
| Name | Type | Size |
|---|---|---|
| Chromogenix Coamatic / Coatest Thrombophilia Flyer | application/pdf | 536.13 kB |
| Chromogenix Coatest APC Resistance Brochure | application/pdf | 107.78 kB |
| Chromogenix Coatest APC Resistance Flyer | application/pdf | 182.93 kB |
| Chromogenix Coatest APC Resistance Monograph | application/pdf | 527.75 kB |
| Coatest APC Resistance MSDS | application/pdf | 122.37 kB |
| Coatest APC Resistance Package Insert | application/pdf | 86.14 kB |
Downloads (Historical Files)
| Name | Type | Size |
|---|---|---|
| APC Resistance ISTH Satellite Symposium Invitation 1997 (old) | application/pdf | 1.37 MB |
| APC Resistance ISTH Satellite Symposium Program & Abstracts 1997 (old) | application/pdf | 118.54 kB |
| Coatest APC Resistance Brochure 1993 (old) | application/pdf | 3.69 MB |
| Coatest APC Resistance Flyer 1994 (old) | application/pdf | 1.92 MB |
| Coatest APC Resistance Flyer 1995 (old) | application/pdf | 2.54 MB |
| Coatest APC Resistance Product Range 1996 (old) | application/pdf | 5.35 MB |