Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) usually found in a complex with proteoglycan. PF4 is a 70-amino acid protein released from alpha-granules of activated platelets during platelet aggregation. The gene for human PF4 is located on human chromosome 4. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair.
| Product | Method/Application | Packaging | CAT # |
|---|---|---|---|
| DiaPharma PF4 | ELISA / RUO | 1 kit, 96 determinations | DPGR006A |
| Plasma PF4 Control | Control / RUO | 6 x 0.5 ml | DPGS013K |
| PF4, human | Bioreagent | 1 x 100 micrograms (1 ml) | PP003A |