DiaPharma Group, Inc.

For research use only. Not for diagnostic procedures.

Composition and purity
Lyophilised powder of human plasminogen prepared from Cohn supernatant by affinity chromatography.
At least 95% of the plasminogen content is Glu-plasminogen. Contains lysine, sodium chloride and glucose.

• Human Plasminogen 1.5 mg ± 0.5
• Glucose 0.9 mg
• Mannitol 20 mg
• Lysine 1.8 mg
• Sodium chloride 2.3 mg

Specific activity
20-40 CU/vial (batch specific).
CU/mg (CU= casein units according to Sqouris et al. Vox Sang 5,357 (1960)).

Application
Determination of streptokinase, tissue plasminogen activator (t-PA), plasminogen activator inhibitor (PAI) and soluble fibrin.

Properties
Plasminogen is prepared from Cohn supernatant I by affinity chromatography (modified procedure according to Deutsch D & Mertz E.T., Science 170, 1095-1096 (1970)).

Storage and Stability
The lyophilized powder is stable at 2-8°C until the expiry date printed on the label. After reconstitution the solution is stable for 8 hours at 2-8°C, 6 months at -20°C. Refreezing should be avoided.

Enzyme Activity Determination
Plasminogen activity can be measured following streptokinasemediated activation to plasmin, using the chromogenic substrates reported below:

• S-2251, 25 mg vial S820332 (820332)
• S-2403, 25 mg vial S822254 (822254)

Related Products:

• Human Plasminogen (Cat. No. PP005A) 200 ug (1 ml)
• Human Plasminogen (Cat. No. PP005B) 1.5 ml (2 ml)
• Human Plasminogen (Cat. No. PP005C) 5 mg (0.5 ml)
• Bovine Plasminogen (Cat. No. BP105C) 5 mg