The assays measure different processes. The Caspase-3 assay measures enzyme activity while the M30-Apoptosense® assay measures the accumulation of a caspase cleaved product. Due to product accumulation over time, M30-Apoptosense® is more sensitive and convenient for screening of many samples. Caspase-3 assays can only be used with samples from cell extracts, while the M30-Apoptosense® assay can be used with culture supernatants and serum or plasma.