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C1 esterase Inhibitor. Complement activity (CH50, CH100, terminal complement component, or individual complement proteins) is measured to determine if complement is involved in the development of a number of diseases. Complement activity is also measured to monitor severity of a disease or determine efficiency of treatment. Patients with hereditary angioedema are often depleted of C1 esterase inhibitor. MEDLINEplus |
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One of the minute blood vessels that connect arterioles and venules. These blood vessels form an intricate network throughout the body for the interchange of various substances, such as oxygen and carbon dioxide, between blood and tissue cells. |
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Any of a group of organic compounds that includes sugars, starches, celluloses, and gums and serves as a major energy source in the diet of animals. These compounds are produced by photosynthetic plants and contain only carbon, hydrogen, and oxygen, usually in the ratio 1:2:1. |
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An enzyme that catalyzes the hydrolysis of the terminal amino acid of a polypeptide from the end that contains a free carboxyl group. |
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The medical study of the structure, function, and disorders of the heart. |
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Disease of the cardiovascular system. |
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Circulatory System. The bodily system consisting of the heart, blood vessels, and blood that circulates blood throughout the body, delivers nutrients and other essential materials to cells, and removes waste products. |
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Individuals who carry the gene for a condition but do not have the condition themselves. |
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The smallest structural unit of living tissue capable of functioning as an independent entity. It consists of a small mass of protoplasm often bounded by a semipermeable membrane, containing usually one or more nuclei and the various nonliving products of its activities, and able to carry on independently all the basic life functions. |
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Competitive Enzyme Immuno Assay |
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The study of the composition, properties and structure of substances, and of the changes they undergo. |
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See FIX hemophilia. |
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Enzymes are proteins that catalyze most of the chemical reactions that take place in the body. The chemical compound upon which the enzyme exerts its catalytic activity is called a substrate. Chromogenic substrates are peptides that react with proteolytic enzymes thus forming color. Attached to the peptide part of the chromogenic substrate is a chemical group which when released after the enzyme cleavage gives rise to color. This leaving group is called a chromophore, and pNA is used in Chromogenix substrates. The color change can be followed spectrophotometrically and is proportional to the proteolytic activity. |
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Peptides that react with proteolytic enzymes thus forming color. |
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A chemical group capable of selective light absorption resulting in the coloration of certain organic compounds. |
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Threadlike structures inside human cells that contain thousands of genes and that are passed down through families. See X-chromosome and Y-chromosome. |
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See Cardiovascular System |
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A salt or ester of citric acid. |
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A gene that has been copied by chemical methods in a laboratory. |
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See Blood Clot |
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The process in which a liquid (blood) turns to a curdlike or jellylike consistency (congeal). |
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As a result of the coagulation process, fibrinogen is split into fibrin monomer and fibrin. Fibrin monomer polymerizes to form fibrin polymer (the clot). Coagulation factor inhibitors and plasmin (which eventually lyses the fibrin clot) are simultaneously activated by damaged tissue, but they function more slowly and over a longer period of time than the coagulation factors. The most important of the coagulation inhibitors is antithrombin III, a protein that requires endogenous (produced by the body) heparin for its activity. |
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Factor IX products which contain very little or no coagulation factors other than FIX, including AlphaNine SD and Mononine. |
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Bleeding disorders. Coagulopathy is a medical term for a defect in the bodies mechanism for blood clotting. While there are several possible causes they generally result in excessive bleeding and a lack of clotting. Hemophilia is an example of a disease (actually several congenital diseases) characterized by coagulopathy; these are examples of severe lack of blood clotting. Acquired causes of coagulopathy include anticoagulation with warfarin, liver failure, and disseminated intravascular coagulation. |
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(CBC) |
Quantitates the number of red blood cells (RBCs), white blood cells (WBCs), the total amount of hemoglobin in the blood, the fraction of the blood composed of cells (hematocrit), and the size of the red blood cells (MCV, mean corpuscular volume). It also includes indices that are calculated from the other measurements. The CBC is a screening test, used to diagnose and manage numerous diseases. It can reflect problems with fluid volume (such as dehydration) or loss of blood. It can show abnormalities in the production, life span, and destruction of blood cells. It can reflect acute or chronic infection, allergies, and problems with clotting. MEDLINEplus |
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Process that initiates the intrinsic pathway of coagulation through contact with a variety of negatively-charged surfaces. |
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A preparation of fresh, frozen or lyophilized plasma collected from human or animal blood or artificially derived material, intended for use in the quality control process. Control plasmas are used to monitor all aspects of the laboratory test system, including the reagents, instruments, reconstituting and diluting fluids and pipettes. Normal controls should give test results within the reference interval. Abnormal control plasmas should give values within the clinically relevant abnormal range. |
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Of, relating to, or being the coronary arteries or veins, or the heart. A coronary thrombosis or heart attack. |
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Either of two arteries that originate in the aorta and supply blood to the muscular tissue of the heart. |
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Any one of the veins that drains blood from the muscular tissue of the heart and empties into the coronary sinus. |
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An unattached body cell, such as a red blood cell or lymph cell. Gray's Anatomy |
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Brand name of Warfarin. |
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A vitamin K antagonist administered orally that is routinely used in the clinical management of thrombosis. |
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C-reactive protein |
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Control Standard Endotoxin |
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Any of several regulatory proteins, such as the interleukins and lymphokines, that are released by cells of the immune system and act as intercellular mediators in the generation of an immune response. |
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The protoplasm outside the nucleus of a cell. |