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Terminal degradation product of a fibrin clot. One of several peptides released as a result of the action of plasmin on fibrin. |
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A condition where there is a blood clot in a deep vein (a vein that accompanies an artery). DVT affects mainly the veins in the lower leg and the thigh. It involves the formation of a clot (thrombus) in the larger veins of the area. This thrombus may interfere with circulation of the area, and it may break off and travel through the blood stream (embolize). The embolus thus created can lodge in the brain, lungs, heart, or other area, causing severe damage to that organ. MEDLINEplus |
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The chemical substance that makes up genes. |
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(DDAVP, Stimate) A synthetic analogue of the natural pituitary antidiuretic hormone, 8-arginine vasopressin. When given to persons who have the capability of producing some FVIII or vWF, the drug effects a rapid, transient increase in FVIII and vWF. It can be given intravenously, subcutaneously, or by intranasal spray. The intranasal spray form is called Stimate. |
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Relating to or containing a pair of bonded nitrogen atoms, one of which is also bonded to an aromatic hydrocarbon. |
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A molecule consisting of two identical simpler molecules. |
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Disseminated Intravascular Coagulation (DIC) |
A disorder of diffuse activation of the clotting cascade that results in depletion of clotting factors in the blood. DIC occurs when the blood clotting mechanisms are activated throughout the body instead of being localized to an area of injury. Small blood clots form throughout the body, and eventually the blood clotting factors are used up and not available to form clots at sites of tissue injury. Clot dissolving mechanisms are also increased. This disorder is variable in its clinical effects, and can result in either clotting symptoms or, more often, bleeding. Bleeding can be severe. DIC may be stimulated by many factors including infection in the blood by bacteria or fungus, severe tissue injury as in burns and head injury, cancer, reactions to blood transfusions, and obstetrical complications such as retained placenta after delivery. Risk factors are recent sepsis, recent injury or trauma, recent surgery or anesthesia, complications of labor and delivery, leukemia or disseminated cancer, recent blood transfusion reaction, and severe liver disease. MEDLINEplusBloodline |
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A condition where the use of certain drugs leads to the formation of antibodies against platelets. If these antibodies are formed during pregnancy, they may pass from the mother to the fetus. MEDLINEplus |
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A reduction in normally functioning platelets that can be caused by certain drugs. Certain drugs may decrease the number of platelets by damaging the bone marrow where platelets are made. Decreased platelets may cause easy bruising or abnormal bleeding. MEDLINEplus |
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Malfunction of fibrinogen in the blood. |