Plasmin Inhibitor (aka Alpha 2-antiplasmin, alpha2-antiplasmin, A2AP, PI) is a serine protease inhibitor (serpin) responsible for inactivating plasmin, an important enzyme that participates in fibrinolysis and degradation of various other proteins.
The gene for A2AP is located on the short arm of the 17th chromosome (17pter-p12).
Very few cases (<20) of A2AP deficiency have been described. As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported.
DiaPharma offers Chromogenix Coamatic Plasmin Inhibitor for the in vitro diagnostic quantitative determination of plasmin inhibitor activity in human citrated plasma using microplate, test tube and automated methods.
Sources: DiaPharma, Wikipedia